Translational research in Tropical diseases, with an emphasis on understanding the immunopathological aspects of Malaria, as well as the discovery of new drugs.
urrently focused on the investigation of the impact of non-coding RNAs, mainly microRNAs and long non coding RNAs, on the modulation of key signaling pathways and its contribution for development of cancer and human infertility, through the use of large scale platforms of gene expression, computational approaches and in vitro and in vivo functional analysis.
The aim of our research is to identify the mechanisms by which the gut microbiota contributes to health. In this context, we are particularly interested in bacterial metabolites called short-chain fatty acids (SCFAs, acetate, propionate and butyrate). These molecules are generated by the fermentation of dietary fibers and play an important role in regulating host metabolism and immunity, being recognized as one of the microbiota-host interaction links.