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Agenda IB
Carla Beatriz Collares Buzato
Our research group focuses on the study of cell-cell and cell-matrix interactions mediated by cell junctions and their role in tissue homeostasis, particularly of epithelial tissue. The current lines of research are: 1) to understand the mechanisms of regulation of intercellular junctions in vivo and in vitro models, 2) to investigate the importance of cell-cell contact mediated by intercellular junctions in the process of cell maturation and dysfunction pancreatic beta during development and in the context of type 2 diabetes mellitus (T2D), and 3) to study the role of the intestinal epithelial barrier mediated by the occlusion junction in the pathogenesis of T2D and its regulation by the microbiota and by short-chain fatty acids. We use in the laboratory a multidisciplinary approach that integrates tissue and functional biology, confocal laser scanning microscopy, electrophysiology, physiology of intercellular/transepithelial transport, and molecular biology (Western Blot and Real-Time PCR) to define fundamentals of the structure and function of cell junctions and understand the regulatory mechanisms of these structures in vivo and in vitro models. This research can contribute to our understanding of the pathophysiological function of junctions and support research aimed at determining ways and pathways for regulating these membrane specializations with possible application in the treatment of certain diseases associated with their dysfunction. (CNPq Group, Communication and Cellular Adhesion).
Valéria Helena Alves Cagnon Quitete
The Laboratory of Reproductive Biology has studied the prostatic microenvironmental changes such as proliferative lesions associated or not with the aging process. The prostatic stroma dynamics as well as the stroma-epithelium interaction have also been the focus of our research, due to the main roles of these glandular compartments in the development and progression of the prostatic lesions associated with inflammation; angiogenesis; and oxidative stress. These studies have used different therapies, including those with natural compounds such as Brazilian berries, and a transgenic adenocarcinoma of the mouse prostate (Tramp) model. In addition to this, biological techniques for instance, immunohistochemistry; western blotting; microdissection; morphology; stereology and PCR have been used. Others studies using human prostatic cells (in vitro) focusing on prostatic cancer; hormonal imbalance; and biological processes (angiogenesis; inflammation; and oxidative stress) have also been developed.