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Agenda IB
Fabio Papes
Prof. Dr. Fabio Papes\\\\\\\' laboratory has two main lines of investigation:
(a) Molecular Studies of the Olfactory System:
In this project, the laboratory intends to understand the molecular bases of the most primitive sensory system found in animals, the Olfactory System, using mice as model animals and Molecular Biology tools. Through genetic manipulation experiments (animal transgenics, optogenetics, chemogenetics and neuronal tracing), the laboratory seeks to understand how odors are detected by the two olfactory sensory organs (main olfactory epithelium and vomeronasal organ), how olfactory information is transferred to the olfactory regions in the brain, and how behavioral responses are generated toward chemical stimuli. In particular, the group studies maternal and paternal behavior, in addition to defensive and sexual behavior. The team has published numerous scientific articles in high-impact journals and has several research collaborations with institutions in Brazil and abroad.
(b) Neurobiological studies of neurological and neuropsychiatric disorders:
Prof. Fabio Papes studies autistic spectrum disorders, seeking to understand their underlying pathophysiology, genetic bases and molecular mechanisms, with the goal of developing pharmacological and genetic therapeutic strategies. Through the use of in vitro cellular models, particularly those derived from patients, the group employs Molecular Biology tools to study autism and its cellular processes.
Prof. Fabio Papes is one of the PIs at the Laboratory of Genomics and Bioenergy (LGE) and at the Center for Medicinal Chemistry (CQMED) at UNICAMP.
Paulo Henrique Ferreira Caria
Morphofunctional behavior of the musculoskeletal system. Currently is collaborator in the OncoTherad nanopharmaceutical development laboratory with application in the treatment of oral cancer.
Marcelo Carnier Dornelas
In the past our group has shown the conservation of the LEAFY gene function and expression patterns during vegetative-to-reproductive transition in tropical tree species. More recently we have been interested on the role of MADS-box genes in defining floral organ morphology and size, using Arabidopsis and passionfruit as models. Current work in our group focus on the molecular networks controlling plant development, taking into account the influences of genomic evolution and the effects of hormones such as auxins, cytokinins and gibberellins. Besides still being concentrated in studying gene function and expression patterns during vegetative-to-reproductive transition, we recently enlarged our interests into floral organ development and evolution as well as tropical fruit development.