Alexandre Leite Rodrigues de Oliveira
Bolsista de Produtividade em Pesquisa do CNPq - Nível 1C

Possui graduação em Ciências Biológicas pela Universidade Estadual Paulista Júlio de Mesquita Filho (1993), mestrado em Biologia Celular e Estrutural pela Universidade Estadual de Campinas (1996) e doutorado em Biologia Celular e Estrutural pela Universidade Estadual de Campinas (1999). Fez pós doutorado no Instituto Karolinska, Suécia (2001-2003). Atualmente é Professor Titular da Universidade Estadual de Campinas. Tem experiência na área de Neurobiologia, investigando processos degenerativos e regenerativos após lesões centrais e periféricas, com ênfase nos motoneurônios medulares, sinapses e reação glial/inflamação. 

 

Artigos Publicados (últimos 5 anos)

 

1. BOMBEIRO, ANDRÉ LUIS ; LIMA, BRUNO HENRIQUE DE MELO ; BONFANTI, AMANDA PIRES ; OLIVEIRA, ALEXANDRE LEITE RODRIGUES DE . Improved mouse sciatic nerve regeneration following lymphocyte cell therapy. MOLECULAR IMMUNOLOGY, v. 121, p. 81-91, 2020.

 

2. BOMBEIRO, ANDRÉ L. ; PEREIRA, B. T. N. ; BONFANTI, AMANDA PIRES ; Oliveira, Alexandre L.R. . Immunomodulation by dimethyl fumarate treatment improves mouse sciatic nerve regeneration. BRAIN RESEARCH BULLETIN, v. 1, p. 1, 2020.

 

3. KEMPE, P. R. G. ; CHIAROTTO, G. B. ; BARRAVIERA, B. ; FERREIRA JUNIOR, R. S. ; Oliveira, Alexandre L.R. . Neuroprotection and immunomodulation by dimethyl fumarate and a heterologous fibrin biopolymer after ventral root avulsion and reimplantation. JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, v. 1, p. 26:e20190093, 2020.

 

4. THEODORO, V. ; FUJII, L. O. ; LUCKE, LETÍCIA D. ; BORTOLAZZO, F. O. ; SILVA, D. D. ; CARNEIRO, G. D. ; AMARAL, M. E. C. ; OLIVEIRA, C. A. ; BOMBEIRO, A. L. ; VICENTE, C. P. ; BOMFIM, F. R. C. ; OLIVEIRA, ALEXANDRE L.R ; BAGNATO, V. S. ; ESQUISATO, M. ; MENDONCA, F. A. S. ; SANTOS, G. M. ; APARECIDA DE ARO, ANDREA . Inhibitory effect of red LED irradiation on fibroblasts and co-culture of adipose-derived mesenchymal stem cells. HELIYON, v. 6, p. e03882, 2020.

 

5. VIEIRA, WILLIANS FERNANDO ; MALANGE, KAUÊ FRANCO ; DE MAGALHÃES, SILVIANE FERNANDES ; DOS SANTOS, GILSON GONÇALVES ; de Oliveira, Alexandre Leite Rodrigues ; DA CRUZ-HÖFLING, MARIA ALICE ; PARADA, CARLOS AMILCAR . Gait analysis correlates mechanical hyperalgesia in a model of streptozotocin-induced diabetic neuropathy: A CatWalk dynamic motor function study. NEUROSCIENCE LETTERS, v. 1, p. 135253, 2020.

 

6. LUCKE, LETÍCIA D. ; BORTOLAZZO, FERNANDA O. ; THEODORO, VIVIANE ; FUJII, LUCAS ; BOMBEIRO, ANDRÉ L. ; FELONATO, MAÍRA ; DALIA, RODRIGO A. ; CARNEIRO, GIANE D. ; CARTAROZZI, LUCIANA P. ; VICENTE, CRISTINA PONTES ; OLIVEIRA, ALEXANDRE L. R. ; MENDONÇA, FERNANDA A. S. ; ESQUISATTO, MARCELO A. M. ; PIMENTEL, EDSON R. ; DE ARO, ANDREA A. . Low-level laser and adipose-derived stem cells altered remodelling genes expression and improved collagen reorganization during tendon repair. CELL PROLIFERATION, v. 1, p. e12580, 2019.

 

7. Cartarozzi, Luciana Politti ; PEREZ, MATHEUS ; KIRCHHOFF, FRANK ; OLIVEIRA, ALEXANDRE LEITE RODRIGUES DE . Role of MHC-I Expression on Spinal Motoneuron Survival and Glial Reactions Following Ventral Root Crush in Mice. Cells, v. 8, p. 483, 2019.

 

8. FRAUZ, KATLEEN ; TEODORO, LUIS ; CARNEIRO, GIANE ; CRISTINA DA VEIGA, FERNANDA ; LOPES FERRUCCI, DANILO ; LUIS BOMBEIRO, ANDRÉ ; WALESKA SIMÕES, PRISCYLA ; ELVIRA ÁLVARES, LÚCIA ; LEITE R. DE OLIVEIRA, ALEXANDRE ; PONTES VICENTE, CRISTINA ; SEABRA FERREIRA, RUI ; BARRAVIERA, BENEDITO ; DO AMARAL, MARIA ; AUGUSTO M. ESQUISATTO, MARCELO ; DE CAMPOS VIDAL, BENEDICTO ; ROSA PIMENTEL, EDSON ; APARECIDA DE ARO, ANDREA . Transected Tendon Treated with a New Fibrin Sealant Alone or Associated with Adipose-Derived Stem Cells. Cells, v. 8, p. 56, 2019.

 

9. CASSARO, C. V. ; JUSTULIN JUNIOR, L. A. ; LIMA, P. R. ; GOLIM, M. A. ; BISCOLA, N. ; de Castro, M. V. ; OLIVEIRA, ALEXANDRE L. R. ; DOICHE, D. P. ; FERREIRA JUNIOR, R. S. ; PEREIRA, E. J. ; BARRAVIERA, B. . Fibrin biopolymer as scaffold candidate to treat bone defects in rats. JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, v. 25, p. e20190027, 2019.

 

10. CASTRO, MATEUS VIDIGAL ; SILVA, M. V. R. ; CHIAROTTO, G. B. ; VOLPE, B. B. ; SANTANA, M. H. ; LUZO, A. C. M. ; Oliveira, Alexandre L.R. . Reflex arc recovery after spinal cord dorsal root repair with platelet rich plasma (PRP). BRAIN RESEARCH BULLETIN, v. 152, p. 212-224, 2019.

 

11.  CHIAROTTO, G. B. ; CARTAROZZI, L. ; PEREZ, M. ; BISCOLA, N. ; SPEJO, A. B. ; GUBERT, F. ; FRANCA JUNIOR, M. C. ; OTERO, R. M. ; Oliveira, Alexandre L.R. . Tempol improves neuroinflammation and delays motor dysfunction in a mouse model (SOD1G93A) of ALS. Journal of Neuroinflammation, v. 16, p. 218, 2019.

 

12. RIBEIRO, P. ; de Castro, M. V. ; PEREZ, M. ; CARTAROZZI, L. ; SPEJO, A. B. ; CHIAROTTO, G. B. ; AUGUSTO, T. M. ; OLIVEIRA, ALEXANDRE L.R . Toll-like receptor 4 (TLR4) influences the glial reaction in the spinal cord and the neural response to injury following peripheral nerve crush. BRAIN RESEARCH BULLETIN, v. 1, p. 1, 2019.

 

13. MORREY, J. D. ; Oliveira, Alexandre L.R. ; WANG, H. ; ZUKOR, K. ; de Castro, M. V. ; SIDDHARTHAN, V. . Zika virus infection causes temporary paralysis in adult mice with motor neuron synaptic retraction and evidence for proximal peripheral neuropathy. Scientific Reports, v. 1, p. 1, 2019.

 

14. Cartarozzi, Luciana Politti ; RIEDER, PHILLIP ; BAI, XIANSHU ; SCHELLER, ANJA ; de Oliveira, Alexandre Leite Rodrigues ; KIRCHHOFF, FRANK . In vivo two-photon imaging of motoneurons and adjacent glia in the ventral spinal cord. JOURNAL OF NEUROSCIENCE METHODS, v. 1, p. 1, 2018.

 

15. MOZAFARI, R. ; KYRYLENKO, S. ; CASTRO, MATEUS VIDIGAL ; FERREIRA JUNIOR, R. S. ; BARRAVIERA, B. ; LEITE RODRIGUES DE OLIVEIRA, ALEXANDRE . Combination of heterologous fibrin sealant and bioengineered human embryonic stem cells to improve regeneration following autogenous sciatic nerve grafting repair. JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, v. 24, p. 1-16, 2018.

 

16. SPEJO, A. B. ; CHIAROTTO, G. B. ; FERREIRA, A. F. ; GOMES, D. A. ; FERREIRA JUNIOR, R. S. ; Barravieira B ; Oliveira, A.L.R. . Neuroprotection and immunomodulation following intraspinal axotomy of motoneurons by treatment with adult mesenchymal stem cells. Journal of Neuroinflammation, v. 15, p. 230, 2018.

 

17. BOMBEIRO, ANDRÉ LUIS ; PEREIRA, B. T. N. ; Oliveira, Alexandre L.R. . Granulocyte-macrophage colony-stimulating factor (GM-CSF) improves mouse peripheral nerve regeneration following sciatic nerve crush. EUROPEAN JOURNAL OF NEUROSCIENCE, v. 1, p. 1, 2018.

 

18. PEREZ, M. ; Cartarozzi, Luciana P ; CHIAROTTO, G. B. ; OLIVEIRA, S. A. ; GUIMARAES, F. S. ; Oliveira, Alexandre L R . Neuronal preservation and reactive gliosis attenuation following neonatal sciatic nerve axotomy by a fluorinated cannabidiol derivative. NEUROPHARMACOLOGY, v. 140, p. 201-208, 2018.

 

19. BERNARDES, D. ; Oliveira, A.L.R. . Regular Exercise Modifies Histopathological Outcomes of Pharmacological Treatment in Experimental Autoimmune Encephalomyelitis. Frontiers in Neurology, v. 9, p. 1, 2018.

 

20. SPEJO, A. B. ; TELES, C. B. ; ZUCCOLI, G. S. ; de oliveira, Alexandre l. r . Synapse preservation and decreased glial reactions following ventral root crush (VRC) and treatment with 4 hydroxy tempo (TEMPOL). Journal of Neuroscience Research, v. 97, p. 1, 2018.

 

21. DE ARO, ANDREA ; CARNEIRO, GIANE ; TEODORO, LUIS ; DA VEIGA, FERNANDA ; FERRUCCI, DANILO ; SIMÕES, GUSTAVO ; SIMÕES, PRISCYLA ; ÁLVARES, LÚCIA ; DE OLIVEIRA, ALEXANDRE ; VICENTE, CRISTINA ; GOMES, CAIO ; PESQUERO, JOÃO ; ESQUISATTO, MARCELO ; DE CAMPOS VIDAL, BENEDICTO ; PIMENTEL, EDSON . Injured Achilles Tendons Treated with Adipose-Derived Stem Cells Transplantation and GDF-5. Cells, v. 7, p. 127, 2018.

 

22. MENDES JUNIOR, D. ; DOMINGUES, J. A. ; HAUSEN, M. A. ; CATTANI, S. M. ; ARAGONES, A. ; OLIVEIRA, ALEXANDRE L.R ; INACIO, R. F. ; BARBO, M. L. ; DUEK, E. A. . Study of mesenchymal stem cells cultured on a poly(lactic-co-glycolic acid) scaffold containing simvastatin for bone healing. Journal of Applied Biomaterials & Functional Materials, p. 1, 2017.

 

23. BISCOLA, NATALIA PERUSSI ; Cartarozzi, Luciana Politti ; ULIAN-BENITEZ, SUZANA ; Barbizan, Roberta ; CASTRO, MATEUS VIDIGAL ; SPEJO, ALINE BARROSO ; FERREIRA, RUI SEABRA ; BARRAVIERA, BENEDITO ; OLIVEIRA, ALEXANDRE LEITE RODRIGUES . Multiple uses of fibrin sealant for nervous system treatment following injury and disease. The Journal of Venomous Animals and Toxins Including Tropical Diseases (Online), v. 23, p. 13, 2017.

 

24. BOMBEIRO, ANDRÉ LUIS ; HELL, RAFAELA CHITARRA RODRIGUES ; SIMÕES, GUSTAVO FERREIRA ; DE CASTRO, MATEUS VIDIGAL ; de Oliveira, Alexandre Leite Rodrigues . Importance of major histocompatibility complex of class I (MHC-I) expression for astroglial reactivity and stability of neural circuits in vitro. Neuroscience Letters (Print), v. 1, p. 1, 2017.

 

25. ARAÚJO, MARTA ROCHA ; KYRYLENKO, SERGIY ; SPEJO, ALINE BARROSO ; DE CASTRO, MATEUS VIDIGAL ; JUNIOR, RUI SEABRA FERREIRA ; BARRAVIERA, BENEDITO ; de Oliveira, Alexandre Leite Rodrigues . Transgenic human embryonic stem cells overexpressing FGF2 stimulate neuroprotection following spinal cord ventral root avulsion. EXPERIMENTAL NEUROLOGY, v. 294, p. 45-57, 2017.

 

26. ASSAF, KYL ; LEAL, CLAUDENETE VIEIRA ; DERAMI, MARIANA SILVEIRA ; DE REZENDE DUEK, ELIANA APARECIDA ; CERAGIOLI, HELDER JOSE ; de Oliveira, Alexandre Leite Rodrigues . Sciatic nerve repair using poly(?-caprolactone) tubular prosthesis associated with nanoparticles of carbon and graphene. Brain and Behavior, v. 1, p. e00755, 2017.

 

27. BERNARDES, D. ; Oliveira, Alexandre R. . Comprehensive catwalk gait analysis in a chronic model of multiple sclerosis subjected to treadmill exercise training. BMC Neurology, v. 17, p. 160, 2017.

 

28.  CHIAROTTO, G. B. ; NARDO, G. ; TROLESE, M. C. ; FRANCA JUNIOR, M. C. ; BENDOTTI, C. ; Oliveira, Alexandre LR . The Emerging Role of the Major Histocompatibility Complex Class I in Amyotrophic Lateral Sclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 18, p. 2298, 2017.

 

29. THOMÉ, RODOLFO ; DE CARVALHO, ANA CAROLINA ; COSTA, T. A. ; ISHIKAWA, L. L. W. ; FRAGA-SILVA, T.F.C. ; SARTORI, A. ; OLIVEIRA, ALEXANDRE L.R ; Verinaud, Liana . Artesunate Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Leukocyte Migration to the Central Nervous System. CNS Neuroscience & Therapeutics (Print), v. 1, p. 1-8, 2016.

 

30. FRERIA, C ; BERNARDES, D. ; LEITE, G.A. ; SIMOES, G. F. ; BARBOSA, G. O. ; Oliveira, Alexandre L.R. . Impairment of toll-like receptors 2 and 4 leads to compensatory mechanisms after sciatic nerve axotomy. Journal of Neuroinflammation, v. 13, p. 118, 2016.

 

31. BOMBEIRO, A. L. ; SANTINI, J. C. ; THOMÉ, RODOLFO ; FERREIRA, E. R. L. ; NUNES, S. L. O. ; MOREIRA, B. M. ; BONET, I. J. M. ; SARTORI, C. R. ; VERINAUD, L. M. C. ; OLIVEIRA, ALEXANDRE L.R . Enhanced Immune Response in Immunodeficient Mice Improves Peripheral Nerve Regeneration Following Axotomy. Frontiers in Cellular Neuroscience, v. 10, p. 1-14, 2016.

 

32. BOMBEIRO, A. L. ; THOME, R. ; NUNES, S. L. ; MOREIRA, B. M. ; VERINAUD, L. M. C. ; OLIVEIRA, ALEXANDRE L.R . MHC-I and PirB Upregulation in the Central and Peripheral Nervous System following Sciatic Nerve Injury. Plos One, v. 11, p. e0161463, 2016.

 

33. Inácio, Rodrigo Fabrizzio ; ZANON, RENATA GACIELLE ; CASTRO, MATEUS VIDIGAL DE ; SOUZA, HENRIQUE MARQUES DE ; BAJGELMAN, MARCIO CHAIM ; Verinaud, Liana ; OLIVEIRA, ALEXANDRE LEITE RODRIGUES DE . Astroglioma conditioned medium increases synaptic elimination and correlates with major histocompatibility complex of class I (MHC I) upregulation in PC12Cells. Neuroscience Letters (Print), v. 634, p. 160-167, 2016.

 

34. BISCOLA, NATALIA PERUSSI ; Cartarozzi, Luciana Politti ; FERREIRA JUNIOR, R. S. ; BARRAVIERA, B. ; OLIVEIRA, ALEXANDRE L.R . Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair. NEURAL PLASTICITY (ONLINE), v. 2016, p. 1-19, 2016.

 

35. VIDIGAL DE CASTRO, MATEUS ; Barbizan, Roberta ; SEABRA FERREIRA, RUI ; BARRAVIERA, BENEDITO ; LEITE RODRIGUES DE OLIVEIRA, ALEXANDRE . Direct Spinal Ventral Root Repair following Avulsion: Effectiveness of a New Heterologous Fibrin Sealant on Motoneuron Survival and Regeneration. NEURAL PLASTICITY (ONLINE), v. 2016, p. 1-16, 2016.