Paulo Guimarães Gandra

Our primary research interest is the investigation of cellular mechanisms regulating skeletal muscle contractile activity and energy metabolism during stimulation and fatigue.
In our lab we are employing an intact single skeletal muscle fiber model that allows us to measure force generation and perform fluorescence microscopy to analyze intracellular parameters in real time during contractions at a single cell level.
Ultimately our long-term goal is to bring new information that might be used to improve muscle function and exercise capacity in different patho-physiological states.

Paulo Sérgio Moreira Carvalho de Oliveira

Ecology and Social Behavior of Ants
Ant-Plant Interactions,
Multitrophic Interactions Involving Ants,
Ant-Plant Mutualisms,
Molecular Ecology of Ants,
Ant-Associated Microbial Communities,
Antipredator Defense in Insects

Helena Coutinho Franco de Oliveira

We have focused on the role of plasma lipoprotein metabolism and associated proteins particularly relevant for the development of atherosclerosis, diabetes and obesity. Hormonal, nutritional and pharmacological regulation of key proteins involved in the metabolism of plasma lipoproteins are investigated with the goal of elucidating molecular mechanisms and putative therapeutic targets for cardio-metabolic disturbances. Scientific contributions have been made concerning the understanding of CETP (cholesteryl ester transfer protein) gene expression and its effects regarding atherosclerosis susceptibility and possible new functions of this protein (Oliveira HCF, Raposo HF. Adv Exp Med Biol. 2020). Together with Anibal Vercesi group, we have demonstrated that mitochondrial bioenergetic function and redox state alterations are present in hyperlipidemic states that predispose to atherosclerosis (Oliveira HCF, Vercesi AE.Mol Aspects Med. 2020)